Isaac Duncan III, a Brooklyn, New York native and Afro-Cuban descendant, received his bachelor of fine arts degree from the University of Notre Dame and certification of  secondary art education from St. Mary's College. In 2001, he was awarded a Lyman T. Johnson Fellowship, from the University of Kentucky, where he completed his Masters of Fine Arts, in Art Studio- Sculpture, in 2004.

Duncan has taught elementary/middle school art in St. Joseph, Michigan, sculpture at the University of Kentucky (during his fellowship), Lexington, Kentucky, and digital image making at Kentucky State University, in Frankfort, Kentucky.

Isaac has been an artist-in-residence for Gallery 37/Archi-Treasures, Toughy Herbert Park and Barbara Gene Wright Complex, Chicago, Illinois, the Richard Hunt Studio Center, in Benton Harbor, Michigan and with the Association of Visual Artist, of Chattanooga, Tennessee, assisting Chakaia Booker.

Isaac was employed by John Henry Sculptor, Inc. for three years, where he was the crew supervisor, heavy equipment operator and assistant to internationally renown sculptor John Henry. As of  mid-2008, Duncan has opened his own studio, Duncan Sculpture and Services, where he create his large scale sculptures and fabrication projects.  In 2009, Duncan was contracted, by internationally renown artist Robert Stackhouse and Carol Mickett, to fabricate their sculpture  “A Place In The Woods,” for the Hunter Museum of American Art. He also teaches as Adjunct Professor at Chattanooga State Technical College.